Musculoskeletal mechanoadaptation

Previous Projects

Bone and cartilage change in the DMM mouse model of osteoarthritis
Osteoarthritis can occur from joint injury. In this work we explore the bone and cartilage changes that occur after destabilization of the medial meniscus (DMM) in a mouse. We use multi-modal imaging to measure changes in tissue structure.
Collaborators: Dr. Tonia Vincent (KIR, Imperial College), Dr. Kathryn Stok (ETH, Zurich)

Modeling osteoarthritis in a murine knee
Axial loading though the knee joint causes region specific lesions in the cartilage. Here we use finite element modeling to determine the stresses in the joint tissue as a function of loading conditions.
Collaborators: Professor Andrew Pitsillides (Royal Veterinary College)

Effects of stem cell therapy on the mechanics of osteogenesis imperfecta (OI) bone
OI or brittle bone disease is caused by a mutation in the collagen protein and results in extremely brittle bones. In this work we examine the effects of stem cell therapy on the mechanical properties of the tissue in OI.
Collaborators: Dr. Pascale Guillot (IRDB, Imperial College London)

Angiogensis in fracture healing
Mechanical stability and blood vessel ingrowth are critical components to fracture healing. In this work we explore how mechanical stability influences blood vessel formation at the fracture site.

Predicting bone deformities in cerebral palsy
Children with cerebral palsy have altered gait and as a result, develop bone deformities. This work uses clinical gait data to determine the loading conditions on the bones. These calculated joint and muscle loads are used in finite element models to predict bone growth.
Collaborators: Dr. Amy Zavatsky, Dr. Julie Stebbins, Dr. Tim Theologis (Oxford University); Dr. Ilse Jonkers (KU Leuven)

Simulating bone formation in a mouse tibial loading model
In an mouse tibial loading model with defined loading we experimentally measure the strain in the bone and construct finite element models of the bone to explore possible mechanical stimuli of adaptation.
Collaborators: Professor Andrew Pitsillides (Royal Veterinary College)

Bone response to whole body vibration
Low magnitude, high frequency vibration of the whole body is osteogenic. This work explore using vibration as a therapy in a mouse model to build stronger bones.
Collaborators: Dr. Pascale Guillot (IRDB, Imperial College)

Ontogenic structural changes in the emu
Emus undergo massive changes in size and shape relatively quickly during growth. This provides an excellent platform for understanding how changes in bone occur in response to locomotor habits.
Collaborators: Dr. John Hutchinson (Royal Veterinary College)