Research


Shefelbine Lab conducts the following research

Musculoskeletal mechanoadaptation


Musculoskeletal mechanoadaptation Bones are responsive to load: with increased loading, bone formation occurs, with decreased loading bone resorption occurs. Our research explores the mechano- sensitivity of bone using clinical observations, experimental models, and computational simulations.

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Advanced skeletal technologies


Advanced skeletal technologies Mechanics play a critical role in musculoskeletal diseases and pathology. When mechanics are altered, the tissue can be damaged (such as in osteoarthritis). In other diseases, the pathology itself causes a detrimental change in mechanical properties of the tissue (such as the brittle bone disease osteogenesis imperfecta). This work uses experimental models of disease to explore the role of mechanics in pathology.

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Multiscale mechanics of bone


Multiscale mechanics of bone Bone is a natural composite material consisting of protein (mainly collagen), mineral (hydroxyapatite), and water. Like many other natural composites bone exhibits a unique combination of mechanical properties, in particular high strength and toughness. This work explores how changes in the bone building blocks at the molecular level influence its hierarchical architecture and how structural features interact across a wide range of length scales.

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